Glossary for single-cell RNA sequencing
Many fields of study use terms that are pretty much restricted to that field of study. This is also true for the field of single-cell RNA sequencing, which itself has different names: single-cell transcriptome sequencing, single-cell transcriptomics, and single-cell gene expression profiling. In this glossary, you can find common terminology from the single-cell RNA sequencing…
Jenine, welcome to the team!
We are happy to announce that Jenine Kruger has joined the team as a Management Executive! At Single Cell Discoveries, she will be responsible for assisting our CEO, COO, and the heads of the departments: Mauro Muraro, Judith Vivié, Bastiaan Bijl, Lotte Koopman, Andrei Prodan, and Dylan Mooijman. She is originally from South Africa where…
Darina, welcome to the team!
We are happy to announce that Darina has joined the team as a Scientist in R&D department, where she will work on improving the currently offered methods as well as broadening our portfolio by developing new ones. She is originally from Slovakia, where she also obtained her BSc at Comenius University in Bratislava after which…
Manon, welcome to the team!
We are happy to announce that Manon Messchendorp has joined the team as a lab technician! At Single Cell Discoveries, Manon will be responsible for sample processing, sample shipments, and lab maintenance. She obtained her BSc and MSc in Biology at the University of Leiden. During her Bachelor’s internship, she tested the anti-inflammatory and antioxidative…
Identification of cell clusters in the human cornea using single-cell RNA sequencing
In this blog, we describe how single-cell RNA sequencing is used to understand the cellular complexity of the cornea tissue. This blog is based on a study published in Scientific Reports in November 2021. The cornea is the part of the eye that allows light to enter and causes refraction of the light. It is…
Prediction of future relapse in MLL-rearranged infant ALL by single-cell RNA sequencing
In this blog, we describe how single-cell RNA sequencing allowed to predict which MLL- rearranged infant acute lymphoblastic leukemia (MLL-r iALL) patients are at risk of relapse. Furthermore, it allowed for characterization of the nature of relapse-predicting cells. Acute lymphoblastic leukemia (ALL) in infants is often driven by a specific mutation, in which a part…
Kelly, welcome to the team!
We are happy to announce that Kelly Klaassen has joined the team as a Marketing Intern. During her internship for Single Cell Discoveries, she will be responsible for investigating the needs and wants of commercial clients, which can be used for improving Single Cell Discoveries’ offerings. Kelly completed her BSc degree in Biology and Medical…
Andrei, welcome to the team!
We are happy to announce that Andrei Prodan has joined SCD as our new Head of Data Science, where he will coordinate the SCD Data Science team, update and maintain the computational infrastructure and bioinformatics pipelines and manage research collaborations and projects. Andrei is originally from Deva, a small town in Transylvania, Romania. After earning…
Our data analysis
How to download your data When your data has arrived and the preliminary analysis has been performed, you will receive an e-mail from our data team to download your data. Your data will be sent with our secured Amazon Web Services (AWS) server. There are multiple ways to download: Your institute uses AWS as a…
General info
This article explains what you can expect from our lab in terms of throughput times, workflows, and lab updates. Requirements Samples are submitted online A printed version of your sample submission is added to the package You have signed a quotation In short, our requirements to start processing are: Before processing, we check if we…
Heterogeneity of regulatory T cells: which type is best for the treatment of inflammatory and autoimmune diseases?
In this blog, we will discuss a study by Sanquin that identified the most optimal T cells for immunotherapy, by using SORT-seq. Adoptive cell therapy (ACT) is a type of immunotherapy in which T cell are isolated from the body, expanded, and placed back. These isolated T cells can be engineered in order to specifically…
Empar, welcome to the team!
During my internship at Single Cell Discoveries I will focus on setting up a pipeline to analyse spatial transcriptomics Visium data, a technique in which the transcriptome of cells is determined and mapped to the location of origin in the tissue. I will also explore different methods to integrate Visium data with scRNA-seq to achieve…