Sofia, welcome to the team!

Sofia will be working together with R&D and Data teams to analyse data coming from the in-house projects. She obtained her bachelor’s in biology at Stockholm University. For her degree project, Sofia studied yeast with impaired Ca2+ homeostasis and the effect of ubiquinone (CoQ) biosynthesis on their survival. She also did one semester of exchange…

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Jenine, welcome to the team!

We are happy to announce that Jenine Kruger has joined the team as a Management Executive! At Single Cell Discoveries, she will be responsible for assisting our CEO, COO, and the heads of the departments: Mauro Muraro, Judith Vivié, Bastiaan Bijl, Lotte Koopman, Andrei Prodan, and Dylan Mooijman. She is originally from South Africa where…

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Darina, welcome to the team!

We are happy to announce that Darina has joined the team as a Scientist in R&D department, where she will work on improving the currently offered methods as well as broadening our portfolio by developing new ones. She is originally from Slovakia, where she also obtained her BSc at Comenius University in Bratislava after which…

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Manon, welcome to the team!

We are happy to announce that Manon Messchendorp has joined the team as a lab technician! At Single Cell Discoveries, Manon will be responsible for sample processing, sample shipments, and lab maintenance. She obtained her BSc and MSc in Biology at the University of Leiden. During her Bachelor’s internship, she tested the anti-inflammatory and antioxidative…

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Prediction of future relapse in MLL-rearranged infant ALL by single-cell RNA sequencing

In this blog, we describe how single-cell RNA sequencing allowed to predict which MLL- rearranged infant acute lymphoblastic leukemia (MLL-r iALL) patients are at risk of relapse. Furthermore, it allowed for characterization of the nature of relapse-predicting cells. Acute lymphoblastic leukemia (ALL) in infants is often driven by a specific mutation, in which a part…

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A human liver model leads to therapeutic discovery for liver disease

In this blog, we will discuss how single-cell RNA sequencing contributed to the discovery of a therapeutic for the treatment of advanced liver disease.   Liver fibrosis can lead to cirrhosis, which is a late-stage liver disease in which a large part of the liver tissue is replaced by fibrotic tissue, and to hepatocellular carcinoma (HCC)….

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Kelly, welcome to the team!

We are happy to announce that Kelly Klaassen has joined the team as a Marketing Intern. During her internship for Single Cell Discoveries, she will be responsible for investigating the needs and wants of commercial clients, which can be used for improving Single Cell Discoveries’ offerings. Kelly completed her BSc degree in Biology and Medical…

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Transcriptome of human FDCs reveals role in antigen presentation to B cells and regulation of T cells 

In this blog, we will discuss the contribution of single-cell RNA sequencing to uncovering the function of human follicular dendritic cells (FDCs) in the germinal center (GC) microenvironment.    The GC is a structure in secondary lymphoid tissues, such as tonsils, in which long-lived antibody-secreting plasma cells and memory B cells are produced. Within the GC,…

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Andrei, welcome to the team!

We are happy to announce that Andrei Prodan has joined SCD as our new Head of Data Science, where he will coordinate the SCD Data Science team, update and maintain the computational infrastructure and bioinformatics pipelines and manage research collaborations and projects. Andrei is originally from Deva, a small town in Transylvania, Romania. After earning…

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Transcription factors EOMES and T-BET regulate maturation of NK cells 

In this blog, we will discuss how two transcription factors influence the maturation of natural killer (NK) cells.   NK cells are cells of the innate immune system and are part of the group 1 innate lymphoid cells (ILCs). NK cells are important for antiviral and antitumor responses. Before NK cells are fully functionally active, they…

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The influence of lipid droplets on brain stem cells 

In this blog, we will discuss how lipid droplets can influence the stem cells in the brain. Stem cells are undifferentiated cells that can develop in different types of cells. In the brain, neural stem/progenitor cells (NSPCs) have the potential to develop into neurons and other brain cells. Lipid metabolism influences the activity of NSPCs….

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