Transcription factors EOMES and T-BET regulate maturation of NK cells
In this blog, we will discuss how two transcription factors influence the maturation of natural killer (NK) cells. NK cells are cells of the innate immune system and are part of the group 1 innate lymphoid cells (ILCs). NK cells are important for antiviral and antitumor responses. Before NK cells are fully functionally active, they…
The influence of lipid droplets on brain stem cells
In this blog, we will discuss how lipid droplets can influence the stem cells in the brain. Stem cells are undifferentiated cells that can develop in different types of cells. In the brain, neural stem/progenitor cells (NSPCs) have the potential to develop into neurons and other brain cells. Lipid metabolism influences the activity of NSPCs….
Heterogeneity of regulatory T cells: which type is best for the treatment of inflammatory and autoimmune diseases?
In this blog, we will discuss a study by Sanquin that identified the most optimal T cells for immunotherapy, by using SORT-seq. Adoptive cell therapy (ACT) is a type of immunotherapy in which T cell are isolated from the body, expanded, and placed back. These isolated T cells can be engineered in order to specifically…
Empar, welcome to the team!
During my internship at Single Cell Discoveries I will focus on setting up a pipeline to analyse spatial transcriptomics Visium data, a technique in which the transcriptome of cells is determined and mapped to the location of origin in the tissue. I will also explore different methods to integrate Visium data with scRNA-seq to achieve…
Identification of a granulysin-secreting immune cell subset in Crohn’s disease patients
In this blog, we will discuss how single-cell sequencing contributed to the identification of a novel immune cell subset in Crohn’s disease. There are many different types of immune cells and within each cell type, various subsets can be distinguished. For example, innate lymphoid cells (ILCs) can be subdivided into five subsets. These immune cells…
Single Cell Discoveries and BioTuring announce collaboration to improve single-cell sequencing research
PRESS RELEASE UTRECHT, January 19, 2022 – Single Cell Discoveries and BioTuring announce a collaboration to improve single-cell sequencing research. As part of the collaboration, Single Cell Discoveries will add BioTuring’s single-cell data analysis solution to its single-cell sequencing services. The collaboration aims to close the gap between single-cell sequencing wet-lab services and single-cell data…
Lovindy, welcome to the team!
We are happy to announce that Lovindy Lebalado has joined SCD as our new laboratory technician, where she will assist in the sample processing pipeline and general laboratory maintenance. Lovindy is originally from Tangerang, a city next to Jakarta, the capital of Indonesia. After she gained her bachelor’s degree in Nutrition Science, she became acquainted…
How to get started with single-cell data analysis
Once you receive your single-cell sequencing data, you can get started with your single-cell data analysis. It can be overwhelming when you first download the data. Here, we’ll give you some tips for the first steps of single-cell sequencing data analysis. Choose your method The first and most important point is that there is not…
Dylan, welcome to the team!
We are happy to announce that Dylan Mooijman has joined SCD as our new Head of R&D, where he will be running our growing R&D department. Dylan is originally from a small coastal village in the western part of Holland but obtained his PhD after working in London, Boston, and finally Utrecht, the Netherlands. After…
How to analyze your Visium data
Recently we have added the 10x Genomics Visium Spatial Gene Expression solution to our portfolio. The Visium workflow generates two types of data: an H&E or Immunofluorescence (IF) tissue image and sequencing data in FASTQ files. But what are the options once you receive your data? Here, we provide you with an overview of tools…
PERSIST-SEQ: a new consortium to build a single-cell cancer atlas
PRESS RELEASE Single Cell Discoveries joins a new international consortium of academic and industrial leaders in the field of cancer research: PERSIST-seq. This collaborative research program aims to provide the cancer research community with a new gold standard workflow for single-cell sequencing by developing and validating best practices as well as generating and analysing…
What is Visium?
Visium Spatial Gene Expression is a spatial transcriptomics solution by 10x Genomics. In a previous blog post, we explain more about spatial transcriptomics in general, which you can read here. Here, we’ll provide you with a quick overview of the Visium Spatial Gene Expression solution, which we recently started offering as a service. A spatial transcriptomics solution Since Visium Spatial Gene Expression is a…