Identification of a granulysin-secreting immune cell subset in Crohn’s disease patients
In this blog, we will discuss how single-cell sequencing contributed to the identification of a novel immune cell subset in Crohn’s disease. There are many different types of immune cells and within each cell type, various subsets can be distinguished. For example, innate lymphoid cells (ILCs) can be subdivided into five subsets. These immune cells…
Revealing an unexpected homogeneity in neuroblastoma
Tumors are usually very heterogeneous and consist of various cancer cell subtypes. Single-cell sequencing can be applied to understand this heterogeneity and often leads to identifying cancer cell subtypes. In this study, there is a surprising outcome: a homogeneous phenotype. In this scientific collaboration between many institutes in the Netherlands and the UK, researchers were…
A bronchioalveolar model for COVID-19
We are proud to present our contribution to the paper An Organoid‐derived Bronchioalveolar Model for SARS‐CoV‐2 Infection of Human Alveolar‐type II‐like Cells, published in EMBO Journal last week. COVID-19 patients can develop life-threatening acute respiratory distress syndrome (ARDS), resulting from a cascade of events triggered by alveolar injury. However, representative in-vitro models to study SARS-CoV-2…
RNA sequencing contributes to new understanding of SARS-CoV-2 in intestinal organoids
A collaborative study of Dutch research groups shows -for the first time- that the SARS-CoV-2 virus is able to infect gut organoids. This research was done at the Hubrecht Institute in Utrecht, the Erasmus MC in Rotterdam and Maastricht University. The results were published last Friday in Science. While the lungs seem to be the predominantly…
A single-celled view of the secret sex lives of African trypanosomes
Single Cell Discoveries is proud to announce the winner of the Single Cell Sequencing Scientific Challenge. In total, more than 30 scientists submitted an abstract, with a highly diverse range of subjects and research proposals. After careful consideration, we have decided to award the free 10x Genomics Single Cell Sequencing project to Prof. Dr. Isabel Roditi from the University…
How to milk a snake without getting bitten
What do you get when you put a well-known snake expert, a famous professor in molecular genetics, and 3 PhD students in a room? TOP-NOTCH SCIENCE! The research, conducted by 3 PhD students from the group from Hans Clevers at the Hubrecht Institute, originally started as a joke at an informal get-together but was published…