Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells

Atherosclerosis might have autoimmune components, Depuydt et al. conclude after 10x Genomics Single Cell Immune Profiling human patient’s atherosclerotic plaques and blood. They observed signs of autoreactivity with foam cells in clonally expanded T-cell subsets.

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

Claireaux et al. aimed to guide vaccine improvement by finding out how the unexposed immune system reacts to the SARS-CoV-2 spike protein. Single-cell RNA sequencing and flow cytometry helped them describe the reactive B cell repertoire. They identified a non-neutralizing antibody class as a main factor in the unexposed SARS-CoV-2 response.