Molecular signatures and cellular diversity during mouse habenula development

The authors performed SORT-seq on mouse habenular neurons at critical developmental stages, instructed by detailed 3D anatomical data. The data reveal cellular and molecular trajectories during embryonic and postnatal development, leading to different habenular subtypes. Among these, the Cartpt+ neuron subtype was studied in-depth and successfully linked to specific molecular and functional properties.

Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy

Wehrens et al. perform single-cell RNA sequencing on the hearts of patients who suffer from hypertrophic cardiomyopathy (HCM). This reveals cardiomyocyte subpopulations, gene regulatory networks, transcription factors, and hypertrophy-related genes that might be relevant to the pathogenesis of the disease.

BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states

Beumer et al. show that the bone morphogenetic protein (BMP) signaling pathway controls the creation of functional zones along the crypt-villus axis. A gene lipid uptake gene signature is enriched in the villus tip and could be therapeutically exploited with BMP inhibitors.