Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint
The authors combined SORT-seq and T cell receptor sequencing to investigate the heterogeneity of regulatory T cells (Tregs) derived from synovial fluid of three patients with juvenile idiopathic arthritis. Results indicate Tregs differentiate to classical effector Tregs or GRP56+CD161+CXCL13+ Tregs. They also found novel predicted drivers of local Treg differentiation.
- DOI: 10.1002/cti2.1420
- PMID: 36204213
- Services: SORT-seq
- Species: Human
- Sample type: Immune system, Synovial fluid