The Prognostic Potential of Human Prostate Cancer-Associated Macrophage Subtypes as Revealed by Single-Cell Transcriptomics

Siefert et al. performed single-cell transcriptomic analysis of human prostate cancer-resident macrophages. They identified three populations. The genes associated with each macrophage populations were used to develop a gene signature which was highly associated with both recurrence-free and metastasis-free survival.