Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism
This study describes an organoid-based model system to study mouse and human thyroid biology. SORT-seq and transmission electron microscopy confirmed that thyroid follicular cell organoids phenocopy primary thyroid tissue. Moreover, the study explores the potential of human organoids for modeling an autoimmune disease, the anti-TSH receptor antibody-driven Graves’ hyperthyroidism.
Barrett’s esophagus is the premalignant condition of esophageal adenocarcinoma. It is categorized into different stages which correlate with the risk of developing carcinoma. Busslinger et al. performed single-cell RNA sequencing to identify seven genes that facilitate the distinction between different Barrett’s esophagus stages on histological sections.