Wattrus et al. establish that hematopoietic stem and progenitor cells (HSPC) are quality assured for stress levels during development. Calreticulin is revealed as an “eat-me” molecule that initiates macrophage-HSPC interaction and leads to programmed cell clearance or stem cell expansion. They used SORT-seq to characterize the macrophage and HSPC subpopulations involved.
How can you explain gastrointestinal symptoms after SARS-CoV-2 infection? Lamers et al. demonstrated SARS-CoV-2 replicates in the enterocytes of human intestinal organoids. Bulk mRNA sequencing showed RNA expression changes in infected organoids.