Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

This paper documents the discovery of a new driver mutation in bladder cancer, present in ~10% of the studied cancer patients. The mutation is a deletion of exons 8 and 9 in the aryl hydrocarbon receptor (AHR) gene. SORT-seq analysis confirmed that a transformed, tumor-related expression profile arose due to mutated AHR in mouse bladder organoids.

Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stroma

What is the cornea made of? Català et al. performed single-cell transcriptomic profiling of 19,472 cells isolated from eight healthy donor corneas. In this paper, they depict the diverse cell populations and provide a comprehensive cell atlas of the healthy human cornea.