Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

With SORT-seq, the authors could obtain high-quality RNA from digested cardiac tissue from adult mice of both healthy and diseased hearts. They identified multiple subpopulations within certain types of cardiac cells and disease-specific cell subpopulations. The results suggest that cytoskeleton-associated protein 4 plays a role in modulating fibroblast activation in injured hearts.