Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects
Hematopoietic stem and progenitor cells (HSPCs) are the disease-propagating cells of juvenile myelomonocytic leukemia (JMML). A SHP2 mutation is common in these patients, and Solman et al. reproduced it in zebrafish. Single-cell mRNA sequencing of HSPCs from mutant zebrafish embryos and bulk sequencing of HSPCs from JMML patients revealed an overlapping inflammatory gene expression pattern. Pharmacological inhibition of the inflammatory response positively impacted mutant zebrafish, suggesting therapeutic possibilities in JMML patients.
Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stroma
What is the cornea made of? Català et al. performed single-cell transcriptomic profiling of 19,472 cells isolated from eight healthy donor corneas. In this paper, they depict the diverse cell populations and provide a comprehensive cell atlas of the healthy human cornea.