The whole-cell pertussis vaccine imposes a broad effector B-cell response in mouse heterologous prime-boost settings
The authors compare effector and memory B cells induced by the two classes of pertussis vaccines (whole cell and acellular versions) using SORT-seq among other techniques. They show that a whole-cell pertussis vaccine prime achieves a more potent and broader memory B cell and plasma-cell response.
- DOI: 10.1172/jci.insight.157034
- PMID: 36136586
- Services: SORT-seq
- Species: Mouse
- Sample type: Bone marrow, Lymphatic system, Spleen