Services

State-of-the-art RNA solutions

We offer multiple single-cell, spatial and bulk RNA sequencing services to best suit your biological question. Looking for a technology we don’t yet offer? Our R&D team is always seeking new challenges.

Trusted by
Mount-Sinai
Hubrecht Institute
Genmab
Heinrich-Heine-Uni
Sanquin

Our technologies

We offer single-cell, spatial, and bulk transcriptomics. Our <R&D team> [link] is actively developing novel single-cell sequencing technologies, multi-omic applications and spatial transcriptomics.

SORT-Seq

Single-cell transcriptomics method utilizing 384-well plates, ideal for low cell counts, FACS sorted populations, and pilot projects. Developed by our founder, exclusively offered by us.

10x Genomics

Certified Service Provider of the 10x Genomics Single Cell Gene Expression and Single Cell Immune Profiling solutions, ideal for high-throughput applications

Vasa-seq

Single-cell RNA sequencing method for full-length and total RNA, ideal for analyzing non-coding RNA and complete transcriptomes. Developed by one of our team members, exclusively offered by us.

bulk RNA sequencing

Comprehensive transcriptome analysis of pooled cell populations, ideal for limited starting material and large projects requiring cell population data.

Spatial Transcriptomics

Transcriptomics method for analysis of spatial gene expression and histology, ideal for the study of cell localization and cell-cell interactions. 

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How we work

Project design

Strategize with our PhD-level account executives to decide between multiple single-cell technologies, including two exclusively offered by us. Leverage our experience with 200+ clients over 1000+ unique projects.

scd-model

Sample processing

Run in our purpose-built single-cell lab with Illumina Novaseq X. Benefit from our experience with 8500+ samples sequenced in 40+ organisms and 30+ tissue types with over 10M cells sequenced.

Data analysis

Gain quick insights into your single-cell data with our preliminary analysis report with QC, clustering, and differential gene expression.Uncover biological insights through custom data analysis with our bioinformaticians who have processed over 50 terabytes of singe-cell data.

 

Why choose Single Cell Discoveries?

We are single-cell
sequencing experts

We are 100% focused on single-cell and spatial transcriptomics, enabling us to take on both large-scale projects and create customized solutions for each client project.

 

Our experience is
unmatched in the field

We have been working in the single-cell field since 2012. Our co-founder and CEO Mauro Muraro published our SORT-seq technology, and our R&D consultant is the mind behind VASA-seq. We have experience in over 40 organisms and 30 tissues and are able to quickly adapt workflows for novel samples.

 

We work as a
collaborative partner

We are dedicated to maintaining a high-touch, collaborative relationship with clients as we scale our capacity to accommodate larger projects. We act as a thought partner and a catalyst for biological discovery.

 

We help you stay
ahead of the curve

We are committed to continuously integrating leading-edge technologies into our service offerings to ensure clients have access to the latest advancements. Our R&D department works to both internalize the best commercial platforms and advance our own single-cell innovations.

 

"The service of Single Cell Discoveries guarantees a smooth process between customer and company. In case of problems or questions, the scientists reacted competently and immediately, so that answers could be found quickly and flexibly. The staff is very friendly in dealing with the customer. Many thanks for the great cooperation."

Prof. dr. Stella Autenrieth & Susanne Pfrommer
German Cancer Research Center

“Fantastic job made by a really professional and friendly team. I strongly recommend Single Cell Discoveries for sequencing services."

Samuel García Pérez
German Cancer Research Center

Case Studies

Learn more about the results of our services—from a client perspective.

Publications

Explore client publications using our services.

Inflammatory Bowel Diseases November, 2022 by Scott A. Jelinsky et al.
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier

Patient-derived organoid models can transform drug discovery for inflammatory bowel disease, but differentiation and functional characterization inconsistencies limit that transformation. Jelinsky et al. profiled molecular and cellular features across a range of intestinal organoid models using bulk RNA sequencing, among other technologies, and examined differentiation and establishing a functional epithelial barrier.

eLife October, 2022 by Alexandra Wiesinger et al.
A single cell transcriptional roadmap of human pacemaker cell differentiation

Wiesinger et al. combine SORT-seq analysis with trajectory inference to reconstruct lineage decisions of sinoatrial node–like cardiomyocytes (derived from induced pluripotent stem cells). WNT and TGFb signaling seem to play a role in these lineage decisions, the authors find.

Journal of Tissue Engineering October, 2022 by Jiuru Li et al.
Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models

The authors directed the differentiation of human induced pluripotent stem cells to three types of heart cell: sinoatrial nodal, atrial and ventricular cardyomyocytes. SORT-seq established that the protocols indeed yielded distinct cell populations in line with expected identities. Such models can progress the use of cardiomyocytes in drug development.

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How can we help?

Want to supercharge your project with single-cell insights?

Connect with our PhD-level scientists to discuss your biological question, timeline, sample types, and other customizations for your single-cell analysis.

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