Use scRNA-seq to
supercharge
your research

Cell Type Identification

scRNA-seq technology can capture gene expression profiles of all individual cells in a tissue at high read depth and increasing scalability. You can thus identify all (even rare) cell types and subtypes and map out the components of highly heterogeneous tissues like brains, tumors, or developing tissue.

In-depth sequencing can reveal cell states and lineages in developing tissues or model systems and characterize how tissues respond to drugs or disease at single-cell resolution.

scRNA-seq is compatible with many species, including all common pharmaceutical model systems and non-animal species.

Immune Profiling

Characterize all functional states of an immune cell population through their gene expression profiles and gain insights into how a body responds to infection or treatment. Moreover, additional T cell receptor sequencing (alpha-beta or gamma-delta), immunoglobulin sequencing, B cell receptor sequencing, and, more broadly, cell-surface protein sequencing (CITE-seq) further contribute to a high-resolution assessment of immune cell clonality.

Highly suitable for drug immunogenicity assessment and immunotherapy, cell therapy (e.g., CAR T-cell therapy), or stem cell therapy development

Biodistribution

Integrate single-cell transgene detection into scRNA-seq full transcriptome profiling to measure the transfection efficiency of gene therapy (e.g. for AAV biodistribution measurements or capsid design) and viral therapy platforms.

Moreover, optimize safety and efficacy of gene editing by validating transgene expression in cells, revealing cell tropism, and studying transcriptomic response after administration. Or measure CRISPR guide RNA transfection at high throughput.

Drug Discovery

Flexible scalability makes scRNA-seq highly compatible with (pre)clinical drug development experiments. For example, compare cell-type compositions or differentially expressed genes in specific cell types between disease states, or responders versus non-responders, and gain insight into drug efficacy and mechanism of action.

Accelerate target and biomarker discovery with high-resolution identification of differentially expressed genes in cells of interest.