Saying goodbye to Anna
As you might know, Anna Alemany was the Head of Data Science at Single Cell Discoveries. Recently, she got the fantastic opportunity to start a single-cell focused research group as a PI at the Leiden Medical University Center. Read on to learn more about her contributions to SCD and her future research. Anna Alemany’s contributions…
A bronchioalveolar model for COVID-19
We are proud to present our contribution to the paper An Organoid‐derived Bronchioalveolar Model for SARS‐CoV‐2 Infection of Human Alveolar‐type II‐like Cells, published in EMBO Journal last week. COVID-19 patients can develop life-threatening acute respiratory distress syndrome (ARDS), resulting from a cascade of events triggered by alveolar injury. However, representative in-vitro models to study SARS-CoV-2…
Single-cell RNA sequencing: the Ultimate Guide
As a scientist, you have probably come across the use of single-cell sequencing in your field. But what is it exactly? And also how can you apply it to your research, which technology should you choose, and what do you need to think about before starting your project? This ultimate guide to single-cell RNA sequencing…
Jan Willem, welcome to the team!
We are pleased to announce that as of November 2nd, Jan Willem Wijnands has joined the team as a Junior Data Manager. At Single Cell Discoveries, he will mainly focus on maintaining and improving the data analysis pipeline. Jan Willem completed this BSc degree in Bioinformatics at the University of Applied Sciences Leiden and his…
Janneke, welcome to the team!
We are pleased to announce that as of October 26th, Janneke Hulsen has joined the team as a Data Intern. During her internship at Single Cell Discoveries, she will focus on the set-up of a pipeline for CITE-seq, a single-cell technique in which oligonucleotide-labeled antibodies are used to integrate cellular protein and transcriptome measurements. Janneke…
How much does single-cell sequencing cost?
Single-cell sequencing can be expensive, especially when compared to conventional bulk RNA sequencing methods. But there is a good reason why this technology is expensive, and you can mitigate these costs if you carefully consider the design of your experiment.
Single-cell sequencing: Research areas
Because of its wide range of applications, single-cell sequencing is applied in many different research fields. This post is a brief overview of some of the areas where single-cell RNA sequencing is being used to advance research.
Single-cell sequencing: Common applications
Single-cell RNA sequencing can be used for almost every biological question that requires a detailed understanding of a cell population. So it’s hardly surprising that it has so many different applications.
Which single-cell RNA sequencing technology should I use?
There are several different technologies to choose from in single-cell sequencing projects. But which one is right to answer your biological question? The answer to this depends on your project. Different biological questions and hypotheses may require different approaches, and therefore a different technological solution. This post explains the most significant technologies, their benefits, and…
How does single-cell RNA sequencing work?
Single-cell RNA sequencing follows a 5-step process and this is true whichever sequencing platform or technology you use. This post is an overview of that process.
Things to consider before you start with single-cell sequencing
Before you get started with your first single-cell sequencing project, there are a few things you need to consider. In this post, we summarize a few crucial points you need to think about before your first single-cell sequencing project: Your biological question Your sample type Your budget Biological question The biological question or hypothesis of your research is your most…
Cell cultures for COVID-19 high-throughput drug development
We are proud to announce our participation in the new public-private partnership project “CLEAR COVID-19,” funded by Health Holland. Together with University Medical Center Utrecht (UMCU), First Health Pharmaceuticals, QVQ Holding B.V., and Vossensteyn Biomedical, we will help develop nasal airway epithelial cell cultures for high-throughput drug development. The focus of the project is to…
