What is Visium?

Visium Spatial Gene Expression is a spatial transcriptomics solution by 10x Genomics. In a previous blog post, we explain more about spatial transcriptomics in general, which you can read here.   Here, we’ll provide you with a quick overview of the Visium Spatial Gene Expression solution, which we recently started offering as a service.  A spatial transcriptomics solution  Since Visium Spatial Gene Expression is a…

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Chalene, welcome to the team!

We are happy to announce that as of July 5th, Chalene joined Single Cell Discoveries as our new Office Manager. Her main focus will be financial administration and HR activities. Chalene has come all the way from South Africa where she obtained her qualification in Marketing and Business Management. She has a strong background in…

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What is spatial transcriptomics?

Spatial transcriptomics is an overarching term for all methods that assign transcriptomics data to the original location within the tissue. Here, we explain why to consider spatial transcriptomics and from which spatial techniques you can choose. A brief history of spatial transcriptomics Although the term spatial transcriptomics was first introduced in 2016, the first steps…

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Update: Visium for FFPE

Recently, 10x Genomics has launched their Visium for FFPE kit. At Single Cell Discoveries, we have decided to include this in our Visium Pilot Program. What is Visium? Visium Spatial Gene Expression allows you to analyze the whole transcriptome of your tissue section. Previously, this was only available for fresh frozen tissue sections. Now, it…

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Becoming a 10x Genomics Certified Service Provider

We are proud to announce that as of March 29, 2021, we are a 10x Genomics Certified Service Provider. We have been certified for the Single Cell Gene Expression and Single Cell Immune Profiling solutions.  What does it mean?  The certification that we received from 10x Genomics means that we perform both methods according to the standards set by 10x Genomics. Therefore,…

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Revealing an unexpected homogeneity in neuroblastoma

Tumors are usually very heterogeneous and consist of various cancer cell subtypes. Single-cell sequencing can be applied to understand this heterogeneity and often leads to identifying cancer cell subtypes. In this study, there is a surprising outcome: a homogeneous phenotype.   In this scientific collaboration between many institutes in the Netherlands and the UK, researchers were…

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Four reasons to collaborate with a single-cell sequencing service provider

Getting started with single-cell sequencing can be overwhelming.  Most academic institutes have single-cell facilities, but if yours doesn’t or you’re looking for other single-cell techniques, you might want to consider working with a service provider.  Here, we explain why you should consider collaborating with a service provider for single-cell sequencing. 

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Single-cell sequencing: core facility or service provider?

When starting with single-cell sequencing, your might ask yourself: do I make use of a core facility or service provider? There are actually three options for single-cell sequencing. You can either make use of the core facility in your institute, outsource your project to a service provider or do everything by yourself. Here, we explain these…

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How to decide your single-cell sequencing parameters

A single-cell sequencing project has different parameters: the number of samples, cells per sample and reads per cell. But how do you decide how many cells you need? Or how deep you need to sequence? Here, we explain what your choice should be based upon. 

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