A human liver model leads to therapeutic discovery for liver disease
In this blog, we will discuss how single-cell RNA sequencing contributed to the discovery of a therapeutic for the treatment of advanced liver disease. Liver fibrosis can lead to cirrhosis, which is a late-stage liver disease in which a large part of the liver tissue is replaced by fibrotic tissue, and to hepatocellular carcinoma (HCC)….
Kelly, welcome to the team!
We are happy to announce that Kelly Klaassen has joined the team as a Marketing Intern. During her internship for Single Cell Discoveries, she will be responsible for investigating the needs and wants of commercial clients, which can be used for improving Single Cell Discoveries’ offerings. Kelly completed her BSc degree in Biology and Medical…
Transcriptome of human FDCs reveals role in antigen presentation to B cells and regulation of T cells
In this blog, we will discuss the contribution of single-cell RNA sequencing to uncovering the function of human follicular dendritic cells (FDCs) in the germinal center (GC) microenvironment. The GC is a structure in secondary lymphoid tissues, such as tonsils, in which long-lived antibody-secreting plasma cells and memory B cells are produced. Within the GC,…
Andrei, welcome to the team!
We are happy to announce that Andrei Prodan has joined SCD as our new Head of Data Science, where he will coordinate the SCD Data Science team, update and maintain the computational infrastructure and bioinformatics pipelines and manage research collaborations and projects. Andrei is originally from Deva, a small town in Transylvania, Romania. After earning…
Transcription factors EOMES and T-BET regulate maturation of NK cells
In this blog, we will discuss how two transcription factors influence the maturation of natural killer (NK) cells. NK cells are cells of the innate immune system and are part of the group 1 innate lymphoid cells (ILCs). NK cells are important for antiviral and antitumor responses. Before NK cells are fully functionally active, they…
The influence of lipid droplets on brain stem cells
In this blog, we will discuss how lipid droplets can influence the stem cells in the brain. Stem cells are undifferentiated cells that can develop in different types of cells. In the brain, neural stem/progenitor cells (NSPCs) have the potential to develop into neurons and other brain cells. Lipid metabolism influences the activity of NSPCs….
Heterogeneity of regulatory T cells: which type is best for the treatment of inflammatory and autoimmune diseases?
In this blog, we will discuss a study by Sanquin that identified the most optimal T cells for immunotherapy, by using SORT-seq. Adoptive cell therapy (ACT) is a type of immunotherapy in which T cell are isolated from the body, expanded, and placed back. These isolated T cells can be engineered in order to specifically…
Empar, welcome to the team!
During my internship at Single Cell Discoveries I will focus on setting up a pipeline to analyse spatial transcriptomics Visium data, a technique in which the transcriptome of cells is determined and mapped to the location of origin in the tissue. I will also explore different methods to integrate Visium data with scRNA-seq to achieve…
Identification of a granulysin-secreting immune cell subset in Crohn’s disease patients
In this blog, we will discuss how single-cell sequencing contributed to the identification of a novel immune cell subset in Crohn’s disease. There are many different types of immune cells and within each cell type, various subsets can be distinguished. For example, innate lymphoid cells (ILCs) can be subdivided into five subsets. These immune cells…
Single Cell Discoveries and BioTuring announce collaboration to improve single-cell sequencing research
PRESS RELEASE UTRECHT, January 19, 2022 – Single Cell Discoveries and BioTuring announce a collaboration to improve single-cell sequencing research. As part of the collaboration, Single Cell Discoveries will add BioTuring’s single-cell data analysis solution to its single-cell sequencing services. The collaboration aims to close the gap between single-cell sequencing wet-lab services and single-cell data…
Lovindy, welcome to the team!
We are happy to announce that Lovindy Lebalado has joined SCD as our new laboratory technician, where she will assist in the sample processing pipeline and general laboratory maintenance. Lovindy is originally from Tangerang, a city next to Jakarta, the capital of Indonesia. After she gained her bachelor’s degree in Nutrition Science, she became acquainted…
How to get started with single-cell data analysis
Once you receive your single-cell sequencing data, you can get started with your single-cell data analysis. It can be overwhelming when you first download the data. Here, we’ll give you some tips for the first steps of single-cell sequencing data analysis. Choose your method The first and most important point is that there is not…
