Use high-throughput single-cell sequencing to identify immune cells
The human immune system is highly complex, consisting of billions of different cells. Single-cell sequencing helps us to identify the immune cell repertoire present in your sample using 10x genomics immune profiling.
Determine receptor sequences
Immune profiling ascertains the sequence of the full spectrum of B-cell and T-cell receptors within a sample. It can be used to determine biomarkers, for example in peripheral blood or tumor tissue.
One of the great benefits of single-cell sequencing in immune profiling is that there is no need to have previous knowledge of potential targets. It allows us to connect two important pieces of information: the immune repertoire information, and cell-type identity, as measured by the single-cell transcriptome.
Identify potential cancer therapies
Immune profiling is not limited to the field of immunology but can be used in all fields where immune cells play a role, for example in oncology. Immune cells are present in the tumor microenvironment, and immune therapies against all sorts of cancers are increasing in number.
These immune therapies are based on the molecular identification of immune cells present and tumor antigens. You can use immune profiling to identify the immune cells present in your tumor and generate potential targets for use in clinical settings.
And much more…
Immune profiling can be used on any sample or tissue where you are interested in mapping the immune cell repertoire.
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