Immune profiling

Use high-throughput sequencing to profile immune repertoires

Use single-cell sequencing to characterize the immune repertoire, investigate the cellular response to pathogens, and pin down autoimmunity mechanisms with immune profiling.

Single-cell immune profiling

Home > Applications > Immune Profiling


The human immune system is an intricate network of billions of distinct cells. Utilizing the high-throughput 10x Genomics Single Cell Immune Profiling assay, we can identify the innate and adaptive immune cells by gene and cell-surface protein expression, full-length V(D)J-sequences for B cell and T cell receptor repertoires, and antigen specificity.

Discover antibody and cell immuno-oncogenic therapies

With the success of immune-based therapies against various cancers, it has become increasingly important to identify immune cells infiltrating the tumor microenvironment and their associated antigens.

By identifying B cells producing antibodies with high specificity and affinity for tumor antigens, you can accelerate the development of recombinant therapeutic antibodies.

Identifying TCR sequences that recognize tumor-specific antigens and neoantigens can help design chimeric antigen receptors that target the same antigens; these CARs can be transduced into T cells to generate tumor-targeted CAR-T cell therapies.

Single Cell Immune Profiling specifics

Map B and T cell clonality

You can identify the full spectrum of B-cell and T-cell receptors present in a sample with single-cell immune profiling. Its unbiased nature enables in-depth study without prior knowledge. By integrating immune repertoire information with cell-type identity as measured by the single-cell transcriptome, you can gain important insights into B and T cell clonality and the immune response to certain pathogens and therapeutics.


Stratify responders and non-responders

Chemotherapy response is known to vary by patient and patient-specific variations in the tumor microenvironment play a role in cancer evolution. Single Cell Immune Profiling can aid in the stratification of response in clinical trials, thereby improving therapeutic strategy success and patient survival.

Case studies

Recent publications

How can we help?

Want to supercharge your project with our services?

Connect with our PhD-level scientists to discuss your biological question, timeline, sample types, and other customizations for your project.