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Pioneering 10x Flex on OCT-Embedded Patient Brain Tissue
10x Genomics opened the gates for single-cell sequencing on non-fresh, non-thawed tissue with their Chromium Single Cell Gene Expression Flex (10x Flex) kit. Now, we have been successful in performing…
Immune Profiling of atherosclerosis reveals new therapeutic potential
A team of scientists uses 10x Genomics Single Cell Immune Profiling to characterize T cells in the atherosclerotic plaque. Their results redefine atherosclerosis as an autoimmune disease.
Mechanism of disease: a new hypothesis for atherosclerosis
To elucidate atherosclerosis’ mechanism of disease, Sheffield University researchers analyzed the transcriptomes of single endothelial cells.
How DRUG-seq Reveals Mechanism-of-Action (MoA)
DRUG-seq is becoming a widely used transcriptomics method to study how compounds affect cellular biology at scale. In drug discovery, identifying compounds that produce a biological effect is only the…
Why a list of genes is not a cell type
Single-cell sequencing is one of the most powerful discovery tools in biology. In a single experiment, you resolve full transcriptomes across every major and minor cell type in your tissue….
How to choose cell number and sequencing depth for your single-cell experiment
There is one question that should precede almost every other decision in single-cell experiment design: “what is the rarest cell population I really care about?” Not which platform to use….