Applications
Applications of
single-cell sequencing
Single-cell RNA sequencing has revolutionized the field of biology by providing a powerful tool to identify cell types, uncover new drug targets and biomarkers, and comprehensively profile the immune system.
THE DRUG DISCOVERY PIPELINE
Get a high-resolution view of your mechanism of action. We support target discovery, mechanism of action analysis, efficacy, and off- target effect studies with the highest-quality single-cell data.
Applications
Cell Type Identification
Identify novel or rare cell types by analyzing gene expression profiles of individual cells and grouping them based on similarities in their transcriptional signatures.
Drug Development
By identifying differentially expressed genes in specific cell types, disease states, and responders/non-responders, single-cell sequencing can accelerate target and biomarker discovery.
Immune Profiling
High-resolution immune profiling provides insight into functional states of immune cells in response to antigenic stimulation and treatment; BCR and TCR repetoire sequencing can provide starting points for immuno-oncology therapeutic development of monoclonal antibodies or cell therapies.
Why choose SCD?
We are single-cell sequencing experts
We are 100% focused on single-cell and spatial transcriptomics, enabling us to take on both large-scale projects and create customized solutions for each client project.
Our experience is unmatched in the field
We have been working in the single-cell field since 2012. Our co-founder and CEO Mauro Muraro published our SORT- seq technology, and our R&D consultant is the mind behind VASA-seq. We have experience in over 40 organisms and 30 tissues and are able to quickly adapt workflows for novel samples.
We help you stay ahead of the curve
We are committed to continuously integrating leading-edge technologies into our service offerings to ensure clients have access to the latest advancements. Our R&D department works to both internalize the best commercial platforms and advance our own single-cell innovations.
We work with you as a collaborative partner
We are dedicated to maintaining a high- touch, collaborative relationship with clients as we scale our capacity to accommodate larger projects. We act as a thought partner and a catalyst for biological discovery.
Case studies
Immune Profiling of atherosclerosis reveals new therapeutic potential
A team of scientists uses 10x Genomics Single Cell Immune Profiling to characterize T cells in the atherosclerotic plaque. Their results redefine atherosclerosis as an autoimmune disease.
Mechanism of disease: a new hypothesis for atherosclerosis
To elucidate atherosclerosis’ mechanism of disease, Sheffield University researchers analyzed the transcriptomes of single endothelial cells.
Drug Discovery
for Precancerous Liver Disease
Here’s the story of how SORT-seq helped advance a novel drug candidate for liver cancer into clinical trials.
Recent publications
Blood
Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response
Clinical & Experimental Immunology
Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis
Nature Communications
Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures
Information Guide
Discover our single-cell sequencing solutions
Download our information guide to access an overview of Single Cell Discoveries, explore our single-cell sequencing services, learn how to get started, and gain more valuable insights.