Applications

Applications of
single-cell sequencing

Single-cell RNA sequencing has revolutionized the field of biology by providing a powerful tool to identify cell types, uncover new drug targets and biomarkers, and comprehensively profile the immune system.

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Single-cell applications at Single Cell Discoveries
THE DRUG DISCOVERY PIPELINE

Get a high-resolution view of your mechanism of action. We support target discovery, mechanism of action analysis, efficacy, and off- target effect studies with the highest-quality single-cell data.

Mechanism of Disease and Biomarker Discovery

Target Identification

Target Validation and Mechanism of Action

Lead Identification and Optimization

Preclinical

Clinical Trials

Applications

Biodistribution

Optimize the safety and efficacy of gene editing by validating transgene expression in cells, revealing cell tropism, and studying transcriptomic response after administration.

Drug Development

By identifying differentially expressed genes in specific cell types, disease states, and responders/non-responders, single-cell sequencing can accelerate target and biomarker discovery.

Cell Type Identification

Identify novel or rare cell types by analyzing gene expression profiles of individual cells and grouping them based on similarities in their transcriptional signatures.

Immune Profiling

Insight into functional states of immune cells in response to antigenic stimulation and treatment; BCR/TCR sequencing guides immuno-oncology therapy development, such as monoclonal antibodies and cell therapies.

Why choose SCD?

We are single-cell sequencing experts

We are 100% focused on single-cell and spatial transcriptomics, enabling us to take on both large-scale projects and create customized solutions for each client project.

Single-cell sequencing service provider

Our experience is unmatched in the field

We have been working in the single-cell field since 2012. Our co-founder and CEO Mauro Muraro published our SORT- seq technology, and our R&D consultant is the mind behind VASA-seq. We have experience in over 40 organisms and 30 tissues and are able to quickly adapt workflows for novel samples.

We help you stay ahead of the curve

We are committed to continuously integrating leading-edge technologies into our service offerings to ensure clients have access to the latest advancements. Our R&D department works to both internalize the best commercial platforms and advance our own single-cell innovations.

We work with you as a collaborative partner

We are dedicated to maintaining a high- touch, collaborative relationship with clients as we scale our capacity to accommodate larger projects. We act as a thought partner and a catalyst for biological discovery.

Case studies

Pioneering 10x Flex on OCT-Embedded Patient Brain Tissue

10x Genomics opened the gates for single-cell sequencing on non-fresh, non-thawed tissue with their Chromium Single Cell Gene Expression Flex (10x Flex) kit. Now, we have been successful in performing…

10x
Neuroscience
Neuroscience
RNA Flex

Recent publications

Information Guide

Discover our single-cell sequencing solutions

Download our information guide to access an overview of Single Cell Discoveries, explore our single-cell sequencing services, learn how to get started, and gain more valuable insights.