Oncology Unravel the complexity of cancer

Single-cell sequencing has transformed cancer research by revealing the heterogeneity and complexity of tumor cell populations and providing insights into cancer progression and treatment resistance, leading to the development of more effective therapies in oncology.

Single Cell Sequencing in Oncology, Single Cell Discoveries
Applications

Single-cell sequencing is an indispensable tool for cancer researchers and those developing immuno-oncology therapeutics for providing novel insights into tumor heterogeneity, immune-tumor interactions, tumor development, and therapy resistance.

Reveal tumor heterogeneity

One of the most popular applications of single-cell sequencing in oncology is to study tumor heterogeneity. Single-cell sequencing data can identify different tumor cell subtypes, often resulting in a single-cell atlas of a specific tumor type. Or, the heterogeneity is studied after the cells have been treated with a compound to assess the effect on different cell types and to determine which cells are driving metastasis or resistance to treatment.

Identify novel therapeutics

Discovery-seq is an ideal readout for large phenotypic screens to identify therapeutic-acting compounds.

Immune cell profiling can be used to identify antibody sequences from B cells for monoclonal antibody development and TCR sequences for cell therapy development.

Study immuno-oncology

Single-cell sequencing is a breakthrough tool for studying immuno-oncology and can provide useful information on how the immune system interacts with the tumor.

The Single Cell Immune Profiling solution by 10x Genomics is highly suitable for studying immuno-oncology. If you want to know more about where the immune cells are located within the tumor, we recommend exploring spatial transcriptomics options.

Read more about Immune Profiling

Explore therapeutic efficacy

Single-cell sequencing enables the detailed analysis of cellular responses to therapeutic interventions at the individual cell level, providing insights into treatment efficacy and potential mechanisms of action. By comparing the gene expression profiles of treated and untreated cells, researchers can identify molecular signatures associated with therapeutic response, revealing the pathways affected by the treatment and informing further optimization of therapeutic strategies.

Read more about drug discovery

Case studies

Amsterdam UMC
December 5, 2023

Pioneering 10x Flex on OCT-Embedded Patient Brain Tissue

10x Genomics opened the gates for single-cell sequencing on non-fresh, non-thawed tissue with their Chromium Single Cell Gene Expression Flex (10x Flex) kit. Now, we have been successful in performing…

10x
Neuroscience
Neuroscience
RNA Flex

Recent publications

How can we help?

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