Unravel the complexity of cancer
Single-cell sequencing has transformed cancer research by revealing the heterogeneity and complexity of tumor cell populations and providing insights into cancer progression and treatment resistance, leading to the development of more effective therapies in oncology.
Single-cell sequencing is an indispensable tool for cancer researchers and those developing immuno-oncology therapeutics for providing novel insights into tumor heterogeneity, immune-tumor interactions, tumor development, and therapy resistance.
Reveal tumor heterogeneity
One of the most popular applications of single-cell sequencing in oncology is to study tumor heterogeneity. Single-cell sequencing data can identify different tumor cell subtypes, often resulting in a single-cell atlas of a specific tumor type. Or, the heterogeneity is studied after the cells have been treated with a compound to assess the effect on different cell types and to determine which cells are driving metastasis or resistance to treatment.
Identify novel therapeutics
Bulk RNA sequencing is an ideal readout for large phenotypic screens to identify therapeutic-acting compounds.
Immune cell profiling can be used to identify antibody sequences from B cells for monoclonal antibody development and TCR sequences for cell therapy development.
Single-cell sequencing is a breakthrough tool for studying immuno-oncology and can provide useful information on how the immune system interacts with the tumor.
The Single Cell Immune Profiling solution by 10x Genomics is highly suitable for studying immuno-oncology. If you want to know more about where the immune cells are located within the tumor, we recommend exploring spatial transcriptomics options.
Explore therapeutic efficacy
Single-cell sequencing enables the detailed analysis of cellular responses to therapeutic interventions at the individual cell level, providing insights into treatment efficacy and potential mechanisms of action. By comparing the gene expression profiles of treated and untreated cells, researchers can identify molecular signatures associated with therapeutic response, revealing the pathways affected by the treatment and informing further optimization of therapeutic strategies.
We offer single-cell, spatial, and bulk transcriptomics.
Our R&D team is actively developing novel single-cell sequencing technologies,
multi-omic applications and spatial transcriptomics.
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Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
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How can we help?
Want to supercharge your project with single-cell insights?
Connect with our PhD-level scientists to discuss your biological question, timeline, sample types, and other customizations for your single-cell analysis.