Single-Cell Sequencing: Instrument-Free vs. Instrument-Based
New methods seem to emerge almost weekly in the rapidly evolving field of single-cell sequencing. This abundance of options can be daunting for researchers as they try to find the…
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Read about our latest news, updates, top-notch science, and learn more about the ins and outs of single-cell sequencing.
Discovery-seq: Finding more and better drug targets
Traditional high-throughput drug screening often relies on visual markers that are challenging to quantify and limited in scope. In contrast, RNA sequencing-based screening offers transcriptome-wide quantitative insights, enabling the discovery…
High-throughput screening: accelerating drug discovery
Drug discovery is a complex and lengthy process that begins with identifying specific molecular targets, such as proteins or genes linked to diseases. Researchers then screen vast libraries of compounds…
Comparing Neutrophil Profiling Methods: Roche’s Findings
Neutrophils are a crucial component of the innate immune system. They initiate the body’s first response to invading microorganisms by degranulation, phagocytosis, and producing Neutrophil Extracellular Traps (NETs). Neutrophils are essential and abundant in both acute and chronic inflammation and are, therefore, pivotal in research on infectious diseases, inflammation, potential therapeutic targets, and cancer.
Single-cell CRISPR Screen – Perturbations at scale
Single-cell CRISPR (scCRISPR) screens have quickly become a game-changer in genomics. scCRISPR screening enables researchers to delve deeply into the functional consequences of gene perturbations at the single-cell level. While…
When and How to Leverage Bioinformatics Consulting Services
Rising to the challenges of single-cell data analysis can be illuminating, or it can be tiresome. That depends on the context of your project, team, skills, and schedule. How do…
Single-Cell Sequencing in Clinical Trials: Phase-II Studies
Today, single-cell RNA sequencing in Phase-II clinical trials serves one main goal. It is used to further develop an understanding of an authorized drug’s mechanism of action, which results are…
Nuclei Isolation for Single Cell: Which Method?
Nuclei isolation — To produce high-quality data with single nucleus RNA sequencing, it’s important first to find the most fitting nuclei isolation protocol. To be more precise, it’s important to…
Single-Cell Sequencing in Clinical Trials: Phase-I Studies
Single Cell in Phase-I Clinical Trials — In this blog post, we take a look at the first documented Phase-I clinical trials that use single-cell RNA sequencing. What have the…
10x Genomics Multiome vs. scRNA-seq and scATAC-seq
10x Genomics Multiome – 10x Genomics’ combinatory technology Multiome Single Cell Gene Expression + ATAC can be a perfect tool for many intricate questions in drug development. In two blog posts,…
How 10x Multiome Works:
A Guide
10x Multiome – Almost all medical diseases in need of new therapeutics—including cancer, immune diseases, and neurodegenerative disorders—result from a complex interplay between gene expression and epigenetic programs. In order…
Exploring the Benefits and Limitations of ATAC-seq in Single Cells
ATAC-seq for single cells — Like any biomedical technique, single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing: scATAC-seq) has benefits and limitations. Some biological questions it is perfectly fit to…