Your daily scRNA-seq data tasks: Tips-and-Tricks
Single-cell RNA sequencing (scRNA-seq) data analysis is not just pressing one button. To get from raw FASTQ files to exploratory reports or publication-ready plots, you will need to: Preprocess your…
Blog
Read about our latest news, updates, top-notch science, and learn more about the ins and outs of single-cell sequencing.
Best Single-Cell RNA Sequencing for Fixed Samples: Flex vs QuantumScale vs Evercode WT
Single-cell RNA sequencing (scRNA-seq) technologies have advanced quickly in recent years. One of the most impactful developments is the ability to work with fixed samples. This innovation allows researchers to…
What Are Your T Cells Really Doing? A Journey Through TCR Single-Cell Data and Epitope Annotation
T cells don’t just patrol the immune system; they remember, recognize, and respond. At the center of this ability is the T cell receptor (TCR), a molecular antenna tuned to…
How to choose the right transcriptomic approach: bulk, single-cell, spatial, or combined?
Different transcriptomics methods offer different levels of detail, cost, and usefulness depending on the type of sample and the research question. Transcriptomics refers to the study of gene expression by…
Beyond Mouse and Man: How to make single-cell sequencing work in non-model species
From corals and camels to companion animals, biologists are increasingly turning to single-cell RNA-seq (scRNA-seq) to explore organisms that fall outside the mouse and human comfort zone. The payoff is…
Long-read sequencing vs full-length sequencing: single molecule resolution or sensitivity?
Demand for high-resolution transcriptome data has risen sharply as questions shift from which genes are expressed to which isoforms, where they are expressed, and when they are expressed. Long-read platforms,…
Single-Cell Sequencing: Instrument-Free vs. Instrument-Based
New methods seem to emerge almost weekly in the rapidly evolving field of single-cell sequencing. This abundance of options can be daunting for researchers as they try to find the…
Discovery-seq: Finding more and better drug targets
Traditional high-throughput drug screening often relies on visual markers that are challenging to quantify and limited in scope. In contrast, RNA sequencing-based screening offers transcriptome-wide quantitative insights, enabling the discovery…
High-throughput screening: accelerating drug discovery
Drug discovery is a complex and lengthy process that begins with identifying specific molecular targets, such as proteins or genes linked to diseases. Researchers then screen vast libraries of compounds…
Comparing Neutrophil Profiling Methods: Roche’s Findings
Neutrophils are a crucial component of the innate immune system. They initiate the body’s first response to invading microorganisms by degranulation, phagocytosis, and producing Neutrophil Extracellular Traps (NETs). Neutrophils are essential and abundant in both acute and chronic inflammation and are, therefore, pivotal in research on infectious diseases, inflammation, potential therapeutic targets, and cancer.
Single-cell CRISPR Screen – Perturbations at scale
Single-cell CRISPR (scCRISPR) screens have quickly become a game-changer in genomics. scCRISPR screening enables researchers to delve deeply into the functional consequences of gene perturbations at the single-cell level. While…
When and How to Leverage Bioinformatics Consulting Services
Rising to the challenges of single-cell data analysis can be illuminating, or it can be tiresome. That depends on the context of your project, team, skills, and schedule. How do…