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From corals and camels to companion animals, biologists are increasingly turning to single-cell RNA-seq (scRNA-seq) to explore organisms that fall outside the mouse and human comfort zone. The payoff is…
Demand for high-resolution transcriptome data has risen sharply as questions shift from which genes are expressed to which isoforms, where they are expressed, and when they are expressed. Long-read platforms,…
New methods seem to emerge almost weekly in the rapidly evolving field of single-cell sequencing. This abundance of options can be daunting for researchers as they try to find the…
Traditional high-throughput drug screening often relies on visual markers that are challenging to quantify and limited in scope. In contrast, RNA sequencing-based screening offers transcriptome-wide quantitative insights, enabling the discovery…
Drug discovery is a complex and lengthy process that begins with identifying specific molecular targets, such as proteins or genes linked to diseases. Researchers then screen vast libraries of compounds…
Neutrophils are a crucial component of the innate immune system. They initiate the body’s first response to invading microorganisms by degranulation, phagocytosis, and producing Neutrophil Extracellular Traps (NETs). Neutrophils are essential and abundant in both acute and chronic inflammation and are, therefore, pivotal in research on infectious diseases, inflammation, potential therapeutic targets, and cancer.
Single-cell CRISPR (scCRISPR) screens have quickly become a game-changer in genomics. scCRISPR screening enables researchers to delve deeply into the functional consequences of gene perturbations at the single-cell level. While…
Rising to the challenges of single-cell data analysis can be illuminating, or it can be tiresome. That depends on the context of your project, team, skills, and schedule. How do…
Today, single-cell RNA sequencing in Phase-II clinical trials serves one main goal. It is used to further develop an understanding of an authorized drug’s mechanism of action, which results are…
Nuclei isolation — To produce high-quality data with single nucleus RNA sequencing, it’s important first to find the most fitting nuclei isolation protocol. To be more precise, it’s important to…
Single Cell in Phase-I Clinical Trials — In this blog post, we take a look at the first documented Phase-I clinical trials that use single-cell RNA sequencing. What have the…
10x Genomics Multiome – 10x Genomics’ combinatory technology Multiome Single Cell Gene Expression + ATAC can be a perfect tool for many intricate questions in drug development. In two blog posts,…