Identify novel drug targets
Identify drug targets and drug-induced gene expression changes and mechanisms behind resistance
Identify cell surface markers
Different cell types have different repertoires of cell surface markers. Single-cell sequencing can be used to identify these cell surface markers. These molecules, apart from performing their biological function, could be of great interest to pharmaceutical companies because they are potential targets for new pharmaceutical substances.
Study drug-induced gene expression changes
Single-cell sequencing can be used to screen candidate drugs and study drug-induced gene expression changes. This sometimes leads to the discovery of a molecular pathway that can be targeted. In complex diseases, the focus is more and more on therapeutics mediating their effect through multiple targets. One effect that these kinds of drug screens have is that drugs originally developed for another disease can be re-purposed.
Find mechanisms behind resistance
Unfortunately, cancer cells have shown to become resistant against targeted therapies. Use single-cell sequencing to identify the molecular mechanism behind resistance and find therapies to target these specific cells.
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