Identify novel drug targets
Identify drug-induced gene expression changes and the mechanisms behind resistance to discover new drug candidates.
Identify cell surface markers
Different cell types have different repertoires of cell surface markers and you can use single-cell sequencing to identify them. Besides performing their biological function, these particular molecules are of great pharmaceutical interest because they are potential targets for new drugs.
Study drug-induced gene expression changes
You can also use single-cell sequencing to screen candidate drugs and study drug-induced gene expression changes. Single-cell sequencing data can also be used to study the effect of a treatment on each cell type separately.
You can then use this to find molecular pathways that are influenced by treatment, and thus pose a valuable drug target candidate.
In complex diseases, the focus is shifting towards therapeutics that mediate their effects through multiple targets. One effect that these kinds of drug screens have is re-purposing drugs originally developed for another disease.
Find mechanisms behind resistance
Unfortunately, cancer cells can become resistant to targeted therapies, but you can use single-cell sequencing to counteract this.
Single-cell sequencing allows you to identify and characterize individual cells or cell populations that can become resistant and the molecular mechanisms driving resistance within these cells.
This opens the way to discovering new compounds to target these pathways.
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